2-hydroxynitrobenzene[qr]
2-Nitrophenol
CAS: 88-75-5
Molecular Formula: C6H5NO3
2-hydroxynitrobenzene[qr] - Names and Identifiers
| Name | 2-Nitrophenol |
| Synonyms | o-Nitrophenol O-NITROPHENOL 2-NITROPHENOL 2-Nitrophenol O-Nitro Phenol 2-nitrophenolate 2-HYDROXYNITROBENZENE 2-Hydroxynitrobenzene 2-hydroxynitrobenzene[qr] 2-Nitrophenol o-Nitrophenol |
| CAS | 88-75-5 |
| EINECS | 201-857-5 |
| InChI | InChI=1/C6H5NO3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H/p-1 |
2-hydroxynitrobenzene[qr] - Physico-chemical Properties
| Molecular Formula | C6H5NO3 |
| Molar Mass | 139.11 |
| Density | 1.495 |
| Melting Point | 43-47℃ |
| Boling Point | 215.8°C at 760 mmHg |
| Flash Point | 97.1°C |
| Water Solubility | 2 g/L (25℃) |
| Vapor Presure | 0.0987mmHg at 25°C |
| Vapor Density | 1 mm Hg ( 49.3 °C) |
| Appearance | Clear pale yellow liquid |
| PH | 5.0～7.0 |
| Storage Condition | 库房通风低温干燥; 与食品原料分开储运 |
| Stability | Stable. Incompatible with strong bases, strong oxidizing agents. |
| Physical and Chemical Properties | Appearance: light yellow soluble in ethanol, ether, benzene, carbon disulfide, alkali hydroxide and hot water, slightly soluble in cold water, can be volatilized with steam. Toxic. There is almond taste. |
| Use | Used in medicine, dye industry, also used as analytical reagent |
2-hydroxynitrobenzene[qr] - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R33 - Danger of cumulative effects |
| Safety Description | S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 1663 |
| WGK Germany | 2 |
| RTECS | SM2100000 |
| TSCA | Yes |
| HS Code | 29089000 |
| Hazard Class | 6.1 |
| Packing Group | III |
| Toxicity | LD50 orally in mice, rats: 1.297, 2.828 g/kg, K. C. Back et al., Reclassification of Materials Listed as Transportation Health Hazards (TSA-20-72-3; PB214-270, 1972) |
2-hydroxynitrobenzene[qr] - Upstream Downstream Industry
2-hydroxynitrobenzene[qr] - Nature
Open Data Verified Data
light yellow needle crystal or prismatic Crystal, melting point 44~45 ℃. Boiling point 216 °c. The relative density was 1. 2941. Refractive index 5723. Soluble in ethanol, ether, benzene, carbon disulfide, alkali hydroxide and hot water, micro-soluble in cold water, can be volatilized with steam. Toxic.
Last Update：2024-01-02 23:10:35
2-hydroxynitrobenzene[qr] - Preparation Method
Open Data Verified Data
- hydrolysis method with O-nitrochlorobenzene as raw material, with sodium hydroxide solution in 0.2~0. 4MPa pressure, 130~150 degrees Celsius temperature hydrolysis, reaction, sulfuric acid cooling, crystallization, centrifugal separation to get the finished product.
- The nitration method uses phenol as a raw material. Nitration by nitric acid to get p-nitrophenol and O-nitrophenol mixture, then by steam distillation, cooling, crystallization, centrifugal separation to get the finished product.
Last Update：2022-01-01 10:50:17
2-hydroxynitrobenzene[qr] - Use
Open Data Verified Data
Medicine, dye intermediates, can also be used as a monochrome pH indicator.
Last Update：2022-01-01 10:50:17
2-hydroxynitrobenzene[qr] - Safety
Open Data Verified Data
- This product is toxic. Flammable. Strong irritation in contact with the skin. Dog intravenous injection LD50 lOOmg/kg. The production site should be well ventilated and the equipment should be closed. The operator should wear protective gear.
- the use of iron drum or woven bag lined with plastic bags, each barrel (bag) net weight 50kg. It was stored in a ventilated and dry warehouse. Keep away from the fire, and do not store and mix with food additives. According to the provisions of the storage and transportation of toxic chemicals.
Last Update：2022-01-01 10:50:18
2-hydroxynitrobenzene[qr] - materialized information
Open Data Unverified Data
Melting point 43-45°C
Boiling point 214-216°C
Density 1.495
Vapor pressure 1mm Hg (49.3°C)
Refractive index 1.5723
Flash point 108°C
Storage conditions Store in dark!
Solubility 2g/L (25°C)
Morphological Liquid
Acidity coefficient (pKa) 7.17(at 25 ℃)
Color Clear pale yellow
Odor Aromatic odor
PH 5.0~7.0
Acid-base indicator discoloration ph range Colorless (5.0) to yellow (7.0)
Water solubility 2g/L (25°C)
Sensitivity Light Sensitive
Merck 14,6619
BRN 775403
Henry's Law Constant At 20 °C: 11.1 at pH 8.1, 11.0 at pH 10.2, 8.9 at pH 11.9, 6.7 at pH 13.7 (wetted-wall column-UV, Zhang et al., 2003)
Stability stable. Incompatible with strong oxidizing agents.
Mainly apply High voltage capacitors, inks, energetic materials, corrosion inhibitors, fertilizer, food storage, enzyme assays, detecting microorganisms, immunotherapy, drugs
Chemical properties light yellow
Used in medicine, dye industry, and also used as analytical reagent
Used as an intermediate for organic synthesis of medicine, dyes, rubber additives, photosensitive materials, etc. It can also be used as a monochromatic pH indicator.
Used as an analytical reagent and also used in organic synthesis
Used as an intermediate for medicine and dyes, and also as a monochromatic pH indicator
Use Determination of glucose and potassium. Organic synthesis. Acid-base indicator. pH5.0-7.0 (colorless-yellow), but the change is not obvious and no carbon dioxide is present).
The production method hydrolyzes o-nitrochlorobenzene with sodium hydroxide solution and then acidifies it. Add 1850-1950L of sodium hydroxide solution with a concentration of 76-80g/L into the hydrolysis pot, and then add 250kg of molten o-nitrochlorobenzene. When the heating is 140-150 ℃ and the pressure is about 0.45MPa, keep it for 2.5h, then raise the temperature to 153-155 ℃, the pressure is about 0.53MPa, and keep the temperature for 3h. After the reaction is completed, it is cooled to 60°C. Add 1000L of water and 60L of concentrated sulfuric acid into the crystallization pot in advance, then press into the above hydrolysate, slowly add sulfuric acid until Congo red test paper is purple, add ice to cool to 30 ℃, stir, filter, and throw off the mother liquor with a centrifuge, so that 210kg of o-nitrophenol with a content of about 90% is obtained. The yield is about 90%. Another preparation method is to nitrate phenol into a mixture of o-nitrophenol and p-nitrophenol, and then distill o-nitrophenol with steam. The nitrification reaction is carried out at 15-23 ℃, and the maximum shall not exceed 25 ℃.
Category toxic substances
Toxicity classification high toxicity
Acute toxicity oral-rat LD50: 334 mg/kg; Oral-mouse LD50: 1297 mg/kg
Flammability hazard characteristics Open flame is flammable; it decomposes toxic nitrogen oxide gas when heated
Storage and transportation characteristics The warehouse is ventilated and dry at low temperature; it is stored and transported separately from food raw materials
Fire extinguishing agent carbon dioxide, sand, foam, water
Dangerous goods mark Xn,T,F
Hazard category code 22-36/37/38-52/53-33-20/21/22-39/23/24/25-23/24/25-11
Safety instructions 26-61-45-36/37-16-7-36-28
Dangerous goods transportation number UN 1663 6.1/PG 3
WGK Germany 2
RTECS SM2100000
Spontaneous combustion temperature 550°C
TSCA Yes
HazardClass 6.1
PackingGroup III
Customs code 29089000
Toxic LD50 orally in mice, rats: 1.297, 2.828 g/kg, k. c. back et al., Reclassification of Materials listed as Transportation health Hazards (TSA-20-72-3; PB214-270, 1972)
Last Update：2024-04-09 19:43:38
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Raw Materials for 2-hydroxynitrobenzene[qr]
Downstream Products for 2-hydroxynitrobenzene[qr]
Carbofuran
BAPTA, TETRASODIUM SALT
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2-Amino-6-bromophenol
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2,6-DINITROPHENOL
2-NITROTHIOPHENOL
3-Nitrosalicylic acid
BAPTA, TETRASODIUM SALT
8-Hydroxyquinoline
2-Amino-6-bromophenol
2-Nitrophenoxyacetic acid
2-(2-MORPHOLIN-4-YLETHOXY)ANILINE
8-Hydroxyquinaldine
2,6-DINITROPHENOL
2-NITROTHIOPHENOL
3-Nitrosalicylic acid